Pei-Wen Chen

Photo of Pei-Wen Chen

Associate Professor of Biology, Chair of Biochemistry & Molecular Biology Program

413-597-3536
Hopper Science Center Rm 130
At Williams since 2016

Education

B.S. National Yang-Ming University (2001)
M.S. Albert Einstein College of Medicine (2003)
Ph.D. Albert Einstein College of Medicine (2008)

Areas of Expertise

Molecular/Cell biology; Biochemistry

Courses

BIOL 222 LEC

Essentials of Biochemistry (not offered 2024/25)

BIOL 410 SEM

Nanomachines in Living Systems (not offered 2024/25)

Scholarship/Creative Work

Research Interests

Roles of Arf GAPs in adhesion-dependent signaling and cancer metastasis

Regulation of higher-order actin structures

Selected Publications

(* Williams undergraduate coauthor; # equal contribution)

  • Rosenberg EM, Jian X, Soubias O, Yoon HY, Yadav MP, Hammoudeh S, Pallikkuth S, Akpan I, Chen PW, Maity TK, Jenkins LM, Yohe ME, Byrd RA and Randazzo PA. NAV-2729 has a complex target profile including multiple ADP-ribosylation factor regulatory proteins.  J Biol Chem. 299: 102992. 2023.
  • Yoon HY, Maron BY*, Girald-Berlingeri S, Gasilina A, Gollin JC*, Jian X, Akpan I, Yohe ME, Randazzo PA and Chen PW. ERK phosphorylation is dependent on cell adhesion in a subset of pediatric sarcoma cell lines. Biochim et Biophys Acta (BBA)-Molecular Cell Research. 1869:119264. 2022. DOI: 10.1016/j.bbamcr.2022.119264.
  • Chen PW#, Gasilina A#, Yadav MP and Randazzo PA. Control of cell signaling by Arf GTPases and their regulators: Focus on links to cancer and other GTPase families. Biochim et Biophys Acta (BBA)-Molecular Cell Research 1869:119171, 2022 (Epub 2021). DOI: 10.1016/j.bbamcr.2021.119171.
  • Chen PW, Billington N, Maron BY*, Sload JA*, Chinthalapudi K and Heissler SM. The BAR domain of the Arf GTPase-activating protein ASAP1 directly binds actin filaments. J Biol Chem. 295:11303-15. 2020.
  • Sztul E, Chen PW, Casanova JE, Cherfils J, Dacks JB, Lambright DG, Lee FS, Randazzo PA, Santy LC, Schürmann A, Wilhelmi I, Yohe ME and Kahn RA. ARF GTPases and their GEFs and GAPs: concepts and challenges. Mol Biol Cell 30:1249-1271. 2019. DOI: 10.1091/mbc.E18-12-0820.
  • Tanna C*, Goss L*, Ludwig C* and Chen PW. Arf GAPs as regulators of the actin cytoskeleton – an update.  International Journal of Molecular Sciences 20: E442, 2019. DOI: 10.3390/ijms20020442.
  • Luo R#, Chen PW#, Kuo JC, Jenkins L, Jian X, Waterman CM, and Randazzo PA. ARAP2 inhibits Akt independently of its effects on focal adhesions. Biol Cell. 110:257-270. 2018. DOI: 10.1111/boc.201800044.
  • Luo R, Reed CE*, Sload JA*, Girald-Berlingeri S, Wordeman L, Randazzo PA and Chen PW. Arf GAPs and molecular motors. Small GTPases 10:196-209, 2019 (Epub 2017). DOI: 10.1080/21541248.2017.1308850.
  • Vitali T, Girald-Berlingeri S, Randazzo PA and Chen PW. Arf GAPs: A family of proteins with disparate functions that converge on a common structure, the integrin adhesion complex.  Small GTPases 10:280-288, 2019 (Epub 2017). DOI: 10.1080/21541248.2017.1299271.
  • Luo R, Chen PW, Wagenbach M, Jian X, Jenkins LM, Wordeman L, and Randazzo PA. Direct functional interaction of the kinesin-13 family member kinesin-like protein 2A (Kif2A) and Arf GAP with GTP-binding protein-like, ankyrin repeats and PH domains 1 (AGAP1). J Biol Chem. 291:21350-62. 2016.
  • Chen PW, Jian X, Heissler SM, Le K, Luo R, Jenkins LM, Nagy A, Moss J, Sellers JR, and Randazzo PA. ASAP1 binds non-muscle myosin 2A to control remodeling of the actomyosin network.  J Biol Chem. 291:7517-26. 2016.

Current Committees

  • Claiming Williams Steering Committee